GENERATION OF HYPOIMMUNOGENIC INDUCED PLURIPOTENT STEM CELLS BY CRISPR-CAS9 SYSTEM AND DETAILED EVALUATION FOR CLINICAL APPLICATION

Generation of hypoimmunogenic induced pluripotent stem cells by CRISPR-Cas9 system and detailed evaluation for clinical application

In order to expand the promise of regenerative medicine using allogeneic induced pluripotent stem cells (iPSCs), precise and efficient genome editing of human leukocyte antigen (HLA) genes would be advantageous to minimize the immune rejection caused by mismatches of HLA type.However, clinical-grade genome editing of multiple HLA genes in human iPS

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Tissue expression of squamous cellular carcinoma antigen and Ki67 in hepatocellular carcinoma-correlation with prognosis: A historical prospective study

Abstract Background Squamous cellular carcinoma antigen Diffuser Oil (SCCA) is overexpressed in hepatocellular carcinoma (HCC) tissue and in sera of HCC patients.Our aim was to assess hepatic SCCA immunostaining in a series of HCCs and to correlate its presence with cell proliferation, apoptosis and clinical outcome.Methods Sixty-one HCC patients w

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